And this brings us back to something that we talked about way back at the beginning of this episode, which was this particular feature of the anti self confabulation, that everything that happens is a reflection that I should say for the Best person that everything that happens is a reflection of how life is bad and their experiences just point to the fact that nothing is going to get better. This is the common language of depression. If this is very depressing to hear me talk about it, is it is heavy. And that's what it's like to to hear these things. It's even heavier, of course, for somebody, to experience them. And those beliefs, those patterns of guilt and grief and anhedonia and delusional anti self confabulations. Those are the things that eventually If they get severe enough, start to convert into things like self-harm mutilation and in the most tragic of cases, of course suicide. And so I think we can look to these treatments such as ketamine and PCP but in particular ketamine and its use in the clinic as ways for people to get distanced from the negative effect that they feel isn't just inside them or overwhelms them, but that for the very severely depressed person, they feel is Is them and we hear the sometimes you are not your emotions, you know, that's a statement that I've always been a little bit challenged by mean. Yes, indeed. Emotions are not who we are. They are states that we go into and out of including happiness and sadness, but they are very much a part of us when we experience them. We don't experience them as next to us or behind us or across the room from us. We experience them as our emotions. They they are so much part and parcel with our experience of our self that a statement. Like we aren't our emotions is a very hard statement to digest especially for the depressed person. And so I think that the nmda receptor and its capacity to induce neural plasticity circuit changes. The fact that PCP and ketamine are both showing activation of neural circuits by way of suppressing activity, the nmda receptor and some of the positive or exciting therapeutic outcomes that are coming from. This really point to the fact that ketamine and PCP and removal of negative. Experiences or the experience of a negative experience, sort of getting meta there, but the experience of a negative experience may be an important path by which people treat their depression, especially in its most severe forms where people are veering towards self harm, mutilation and suicide. So you may have noticed a theme which is that certain categories of approaches that we've been discussing for offsetting that symptoms of depression such as exercise ingesting epa's, reducing inflammation, or even the Surprise for increasing serotonin, focus on changing some core biological function like raising the amount of a chemical serotonin or reducing the amount of inflammatory cytokines in the brain and body. And yet things like ketamine, focus more on rewiring circuitry, changing neural circuitry so that it functions better in the immediate and hopefully in the long term as well. And keep people with major depression in what they call remission away. From major depression.