but you're describing pain and the Formation response and the hyperalgesia the increase in pain in that general area as something very adaptive very important. So it raises the question. What is the threshold for saying that somebody should treat their pain reduce their pain? I mean, you know anytime I've done, you know surgeries on animals, which I don't do anymore in the laboratory, but we used to you know, you would give them pain killers postoperatively. I've had surgeries before I had painkillers postoperatively, although I don't Don't like taking them. I don't like the way they make my brain feel and so but we of course know that if you increase the dose of any pain medication too much then that animal or a human can potentially injure themselves worse or not protect that injured area. So it raises a whole set of sort of medical ethical but also just purely biological questions. How do you set the threshold for? Yes blunt pain versus no allow the pain to be there as an Adaptive way of protecting yourself and healing Presumably the inflammation is part of the healing process to and as you mentioned before pain is so subjective and it's different between all of us. I mean, how do we decide whether or not it's a good or bad idea to blunt that pain? Yeah.

I think the the threshold is when it's impacting your quality of life and your ability to take care of the activities of daily living engage with family friends go to work and That that serves kind of a your threshold for you know, whether it's reasonable to take a medication or not. It's a lot of controversy in the space right now used to be we all recommended just NSAIDs for any type of acute injury. I don't permit

a non-steroidal anti-inflammatory drugs indeed. Could it could we maybe list off a few of those? So I mentioned ibuprofen acetaminophen? So sometimes referred to as you know, the classic Advil Tylenol, we will throw out a name brands there. But what are some others naproxen and

the There's another one toward. All our cue to row lack is another one the to over-the-counter NSAIDs the prototypical over-the-counter ones or ibuprofen and Naprosyn. Those are the ones you can buy over the counter without a prescription. Tylenol actually has a slightly different mechanism of injury, but you know still fits in that same general class. It tends to be more centrally acting I be Tylenol or acetaminophen but takes a centrally

you mean brain, right? Thank you thank and brand is aspirin. Considered an end side. I don't

yeah, I would it would fit into that category of basically a (expletive) cyclooxygenase inhibitor. This is one of the chemical mediators that gets released during injury and that chemical substance has a tendency to wind up or amplify the nociceptors so that after an injury, you note that you're more sensitive thereafter a sunburn you end up having more sensitization. That is what we refer to. To as peripheral sensitization because it's out in the periphery were winding up or amplifying the response aspirin NSAIDs in general will reduce that inflammation their anti hyperalgesia.