Do we need test gets unless we can widely distribute them in which case of course we need them so we can map the thing out. But until then, I mean should we only reserve them for high-risk people? I agree. I think that it's the same for chloroquine for Plateau as it's known right now the doctors the that I know that Romney's on the front lines as we say, it's it's desperate times and we need to keep them healthy. Otherwise, we're all in trouble.
Bulletproof radio state of high
performance you're listening to bulletproof radio with Dave asprey.
Today's cool fact of the day is that it's now possible to predict empathy in brains, even when they're at rest and you might be saying Dave what the hell you're recording this in the middle of a pandemic and you're talking about empathy. You're a bad person. Well, it's exactly that part of your brain that I'm talking to right now because it turns out you Celia scientists have shown is possible to predict empathy from brain activity when you're just chilling, which is what you're supposed to be doing right now. Unless you're trying to work from home over internet technology that only kind of sort of works.
In this new study researchers want to know how accurately they could predict whether someone is likely to be empathetic or not, which is really a big deal. So they just said hey, what does your brain do when you're not paying attention using fmri, and then they use machine learning which is the cool stuff and what they found was just looking at brain waves were comparable to questionnaires that they use for standard empathy assessment. So what you do when you're not paying attention is as good as you filling out a survey to figure out whether you really really really give a shit about
Other people are not one other thing you could do to measure that would be have you decided that you're going to stay at home, even though you're personally at low risk of getting this covid virus and the answer there is well, if you are staying at home and limiting your exposure to others, you probably have some empathy to for others or at least you're susceptible to shaming which is what I'm doing right now.
On that note. This is a special episode focused on the covid on pandemics on the coronavirus with one of the really smart groundbreaking amazing humans working in the anti-aging field a guy who's been on the show before very very popular guest. He's been on the Joe Rogan show many many national TV and radio shows talking about how we're going to live way longer than anyone thinks and so we're in alignment on that and one of the things that matters to living a long time is
Well, not dying Step 1 and we're going to talk about the pandemic. I'm talking about none other than dr. David Sinclair who is a professor in the department of genetics at Harvard medical school and he looks at biological mechanisms of Aging at Harvard and is just a shockingly smart guy. If you haven't read his anti-aging Opus just came out lifespan you're missing out and since you don't have to commute you should read it right now on that note.
Dr. David Sinclair, he PhD not MD welcome to the show. Tell us about your research brain and what you've looked at about covid and we're going to go deep on this virus. Hey Dave. Thanks for having me back on. Yeah. It's a very interesting time for trust scientists. Well, I've been very busy. I'm also a microbiologist. I'm a geneticist. I've got a company working on the front lines making test kits to discover.
And track the virus. So yeah, it's been very busy these last few weeks. I think a lot of us thought that we might have some time off with our families being sent home. We wound our lab down a couple weeks ago, but it's been busier than ever and mainly because I think we all or most of us want to be useful and the way I'm being useful is talking to people my friends on the front line trying to distribute Goods to people I know in the industry as well as kits from China. It's been crazy.
Is it kind of creepy that in lifespan? This is your book about how we're going to live a long time. You actually call out the 1918 influenza H1N1 and you say straight up the gains in life expectancy. We've witnessed over the past hundred twenty years could be wiped out for a generation unless we address the greatest threat to our lives other life forms that seek to prey on us. Do you have a crystal ball or you're just generally worried about that on principle?
I know I'm generally worried about that before this happened. It was pretty obvious to me as someone who was already working on a company that was detecting viruses that these things were going to attack. You know, Bill Gates was sounding the alarm years ago, you know, unfortunately, it's come it's here though. It's not the worst virus that could have come it is really bad, but I think it's also a good it's good practice for the
Really big one. That's probably going to come later in our lifetimes. I want to ask you the most awkward question that maybe on a lot of people's minds and I mean to sound like a total jerk for asking it.
Is covid-19 taking out people who were going to die of other things anyway, because they were unhealthy in other words in Italy, you know, the average age was 80.1% the average person who died had three other serious comorbidities. They were already I'm going to call it half dead not in a bad way, but I respect my elders. The older someone is the more I want to interview them because they have the most mileage to share but it is this is this as big of a threat as
You think it is given that it seems to be taking out the people who are vulnerable who are going to get really harmed by almost any infectious thing. These are the people who died of pneumonia who died of flu who died of cardiovascular failure because they're near the end and because their biological energy is and where it should be is that a question is even worth asking or am I just a jerk?
Well, no comment. I'm just a jerk. Yeah, thanks, man. Well, you know, I work at Harvard Medical School our goal in life over there is to keep everybody alive and healthy as long as we can. That's what we had pledged. It's a noble goal and I'm not I'm not saying anything bad about that. I support it. The thing is you guys kind of suck at it. I mean, I hate to tell you these people are already there suffering from three.
Comorbidity is they have cardiovascular disease. They have cancer. They have diabetes. You didn't solve those yet. So are not what else is gonna come along and be the straw that or the whatever the piece of straw that breaks the camel's back. Okay, mr. Controversy. Are we so not everyone has illnesses underlying illnesses. Let's die. That's important yesterday. I was aware of someone I might Network who died at age 29. Okay, who is healthy?
So there's bad stuff happening, but you're right. There are a lot of people who haven't taken good care of themselves in life. They've got diabetes. They've got heart disease or they just aged and the reason that I wrote my book is to say we don't have to all end up like that. There are things you can do in our lives as you know, I follow your staff we can push that off till much later and be healthy in our 80s and even now 90s and if you're healthy and you're 80s and 90s, it's unlikely that this is going to get
You okay? Let's affect one of the most popular videos I've done on Instagram. I hashtag that Corona muffin and I was looking like I was eating a big sugary muffin from a green light. And the reason was popular, isn't it guys I'm flying home and I'm going to go self isolate because I don't want to hospital search and I'm doing it for you because you're older you have more knowledge because your immunocompromised whatever the deal is, but I'm buying you time and so we're you know billions of
other people so that you can take steps right now to become more resilient.
How realistic is it that someone who's at moderate risk of having something serious happened that they can move the needle and the next 60 or 90 days to become a little bit less than moderate risk like how fast does it move?
It can move really quickly. I mean, you're not going to cure your diabetes in a few weeks. That would be on you can lower your blood sugar right? You can definitely so, you know, I agree with what you're saying, which is if you ever had a good motivation good reason to stop being healthy and stop eating crap and eating lots of sugar and processed food, especially the sugar and carbohydrates now is that time stop it right now and then move get up off the couch. Don't don't just
Movies in the spare time that you have now moved go. If you can't get out of the house, some of us are lucky. I'm lucky here to be on Cape Cod we can go for a walk. But if you're in the middle of New York star jumps or something like that what I'm doing every time that jumping jacks for okay guys. Yeah, it's all right. Just making sure. Yeah, I still have some Australian in me the but what I've done so I used to do workouts professional not professionally, but with the trainer every Sunday.
For two and a half three hours. I've now said, you know, I'm 50. I'm at risk. I'm going to get even further than I was already. I'm eating better. I'm trying to eat super healthy, but I also I've upped my exercise. I'm now exercising as much as my body can take at my age. So I'm doing at least three days a week of high intensity exercise as well as weight lifting with it with a trainer through the internet this cardio or
Is this weights? It's mostly white a lot of hip hinge lot of big muscles trying to get get those strengths. And but also I need to get we all need to get our lungs in order. That's what's going to be attacked first. And that's why I probably will do us and if we get this, so to two questions for you there one is I've seen studies that say that doing lots of endurance cardio might make you at higher risk or lower your immunity. So is that an issue? I mean if someone's going to be going to spin for three hours
A day. Is that going to be worse than spending for an hour a day or doing something else? Yeah. Yeah, I've seen that. So what I'm doing is is short bursts of high-intensity interval training. There's so much evidence behind that. It means I'm one of many voices for years have been saying guys, this is what science says. So you're on board with that. What about this overtraining phenomena when people have lots of emotional strats lots of loneliness stress. Lots of job stress IE 10 million people probably just got laid off last week.
And maybe they're not sleeping very well as a result of it. Do they really want to do high intensity interval training or is it going to actually mess with their cortisol so much that their risk goes up.
Well, you do what feels right to you, I think but I think that the fact that we're indoors and all going slightly crazy exercise is really good stress. So you've got to move and you've got to do enough exercise or stress, but maybe not get fully exhausted every single day. Yeah. Yeah. You don't want your body to be damaged too badly. So I work out enough so that I feel a little bit sore the next day but not a lot not alone don't want really overdoing it at this.
That's true. The reason I'm calling this out is that the average human on earth is probably as an issue. There's a lot of bulletproof people who are like, you know, I'm a senior executive at my company and I'm going to do Iron Man and I'm going to start a new company and I'm going to write a book and like they're a little bit nuts. And so if you're one of those human beings who is listening to this look there is a wall and you can use bulletproof and you can realize and you can move the wall way out but you can still go so fast because you built up speed they hit the wall now is not the time to blow out your biology with you.
No, Ultra, ultimate endurance training. So yes, stay really strong and I'm with you there. Okay, next up General actions for virus immunity things that you're thinking about and I want you to talk about supplements drugs, whatever you can because you're one of those researchers who's willing to hey, look where's ferret role does. So here's how I take it in the morning. So you're you're willing to put one foot on either side of the fence instead of being dogmatic on either one. So give it to me straight. How do I make myself?
Stronger against viruses and then we'll go into specifically this one sure. Well, there's plenty of drugs but that are being tested but we can maybe touch on those later. We don't all have access to those. But what I'm doing at home is keeping up my vitamin D levels. That's clearly important. Rhonda Patrick has talked about that online. I'm still skipping breakfast and try and eat a very late lunch. I didn't eat lunch today till about four o'clock today.
So that period of intermittent fasting has been shown at least in animals are to boost the immune system and shut down chronic inflammation. So continuing to do that, but I'm not starving myself. I'm not doing three days fasting. I think that that might put your body like you say into a bit too much stress, but I am trying to get my blood sugar down. My blood sugar is typically a bit above what I would would like I'm not diabetic yet, but I'm doing what you said, which is avoiding.
Eating these these Donuts. I don't need them normally, but it's even harder now that we're at home and it's easier to just go to the cupboard and snack on something or keep Donuts at home.
No, but but my kids I've got three teenage kids and they have a fair amount of crap. If it all disappeared. They wouldn't be able to go out and get more. I mean what is time to put him on a good diet, by the way, they hate me right now for saying that I'm just kidding. Yeah, babe. Hey, if you did that I get it. Look my lovely wife Sandra's cooking Vienna schnitzel for dinner animal, which it's going to be good occasionally got to live a little but mostly I'm trying to be very healthy with what I eat and how much I eat in terms of the ACT.
Food I'm trying my best and I think we should all try our best to still eat fresh food, but it's getting harder and harder for obvious reasons. But if you can't eat Super Fresh Food, what I'm turning to is quote unquote fresh frozen food. I think that's still better than the cans and the boiled pasta that a lot of us are turning to join this time. I was I was really refreshing to see a photo of the of the shelves at a Whole Foods the entire post. I'll been cleaned out except for garbanzo bean pasta.
No one would touch that shit. Garbanzo beans are nasty. Okay, this is proof. It's I'd rather starve than eat garbanzo bean. So if you're one of the people skipped over those Hallelujah, brother. All right, so I would say garbanzo beans are inflammatory, especially pasta like stuff for a lot of people are there specific foods that you would say, like don't do that. I'm swimming sugars there. But are there other Kryptonite Foods in your own program or your own house that you like? I'm not going to do that. Probably about half of what's in the political now the truth comes out cover Jamie.
I'm pretty strict on that, but that's okay. So what would you not eat though? Like the you think people are eating maybe mistakes? They're making
Well, I don't know Dave. Did you ever wear a one of those glucose monitors to see how your body products? I just finished three months. I've got a new order of them that just came in. So I'll be sticking one on later today the see GMC. Yeah. Yeah, so I was wearing one. I don't have one right now, but I learned a lot about my body just like I was talking with Rhonda Patrick about this the white rice wild rice shoots our blood sugar way up. And so I try to avoid any rice, but particularly white rice.
It's interesting. So we're opposites there. So for you, is it pre I mean everyone responds differently to different different carbs what I'm doing with white rice because it's one of the ones has the least amount of inflammatory other molecules. Attach the provides a source of starch is I will put a brain octane or as some people do coconut oil. I just don't like that taste while it's cooking and then you can cool it and when you cook it and cool it it makes a lot of resistant starch and then what I'm doing is I'm pounding it into a Japanese.
Thing called Mochi and then I add 2 cups of inner fuel which is a Prebiotic and at that point it tastes amazing, but I'm getting so much filling stuff. You can eat very much and I've blunted whatever blood sugar I was getting but even then I'd rather have a little bit of sushi with a lot of a lot of fat and fish and some sushi rice than zero carbs for years on end because that seems like that might not be good either but for you it singeing rice is just off of everything what about gluten and flour and things like that. Is that also
Well, I'm also my wife is also a baker aside is fresh bread in the house. It's hard man. I try not to eat bread. Just I also found that was really bad my glucose to shoot up. So what I try to do, I that we've vegetables in the fridge. So when I'm feel like snacking, I'll grab some little baby carrots and that kind of stuff some pickles. I find a pretty good that's that's my go-to fruit. We are running out of fresh fruit, but usually,
Grab an apple if I'm in need of some sugar and that's I think that's a better thing for most people is a slow-release sure eating eating grapes is from the is terrible. Perhaps I'll do it. Just pop up a cube of sugar into your mouth. Yeah. So so sugar controls big sugar down, let's talk about vitamin D3. So I mean everyone in my community is going back 20 years has been saying vitamin D3 or the anti-aging nonprofit silk.
On Valley crowd and overtime at first I was saying don't take vitamin A because it actually fights against vitamin D3 but the evidence over the last 10 years has come in that you need some preformed vitamin A not that beta carotene vegetable crap, but the kind that comes from actually eating liver or eating animals. And so today my recommendations are vitamin D3. It's usually 10,000 maybe even 15,000 I use but 10,000 IU's of vitamin A.
And if you start getting sick taking a hundred thousand I use a vitamin A and cranking up your vitamin D for that first three days. Have you seen anything about that? You have any thoughts about a versus d?
Well, I know a little bit about D not so much about a sounds like you're the expert in this conversation. I mean, I know about vitamin D and the immune cells require certain amount and I know by measuring myself. I also use inside track or where I consult in full disclosure. And so I know my vitamin D levels drop quote unquote dangerously low during winter. So I'm trying to make sure that that doesn't happen. So I'm taking at least
And it's a day with my family as well, but it's pretty clear that if you don't keep the levels of vitamin D up at the same levels as you have in summary, you can lose some of your immunity and now would not be the time to do that. Okay? What about Resveratrol NAD things like that? What's your take for viruses?
Yeah, so I've been looking at this a lot because I'm asked every day by people on the internet now that the issue with these two molecules in terms of giving a straight answer is that there's evidence before for and against and most of it comes from animals, but I can you know, just for the sake of discussion I can tell you what I've learned so that the genes that we work on.
They called sirtuins and anyone who's read. My book will know a fair bit about these the genes make enzymes that control our body's natural defenses against any insult whether its diseases of Aging or infections. And in fact, the sirtuins are very good at combating viral infections in the petri dish and in some cases in my sweats being tested and I tweeted about this this morning actually.
We now realize is that these sirtuins they need in ad to work and we also have shown many times that Resveratrol is an activator. And the way to think of it is that NAD is the fuel for the sort of two and enzymes and the Resveratrol is the accelerator pedal.
Now even though that all sounds great you might say well I'm just going to go and get myself grams of NAD precursors to raise my ID and I'm going to take Resveratrol. There's some caveats one is that Resveratrol can in mice raise the levels of the ace to protein the enzyme on the outside of your lung cells your epithelial cells and that would be a bad thing right? You don't
Let the virus have more targets to get into cells. I think probably everybody is now knows that that is how the virus gets into our body. And by the way smoking specifically in the lungs inhaling vaping or smoking raises a stew on in your lung tissues, which is one of those reasons that smokers really get Trashed by the virus, right? Yeah. I'm sure that that's part of it. There's all sorts of problems and smoking truth including increasing your biological age.
Age which is I think part of the whole problem for the people who are succumbing. So the let's see. So we've got the the Resveratrol is include increasing age to oh, by the way while we're on the topic these beta blockers the the H2 inhibited. I don't want anyone to panic they should consult their doctor, but there's a discussion among scientists that it might actually not protect against the virus but make things potentially.
We were spy up regulating going to cause you to make more Ace 2 receptors because you don't have enough a stew because you didn't deal with your stress problem. Yeah, I mean exactly I hate to put it that bluntly but I have some very close friends. I've said look, I know you have stage fright you almost wet your pants your you know, a forty-year-old grown man taken, you know, take a beta blocker before you go on stage and there's like, oh my God, I can speak again. I'm like, yeah, but you haven't dealt with your underlying stress condition. You've just hacked the problem.
So maybe four people on blood pressure blood pressure meds like that. It's not time to panic but get yourself on masks and some gloves and some hand sanitizer and be a little more religious about your social distancing that you already are supposed to because you should put yourself in the I'm at high risk category until we know more true statement.
Yeah, I think avoiding medicines when you can change your lifestyle is always preferable. Even if you go off of your blood pressure medication tomorrow and you don't you die of popping a vein, which is a risk if you do that or your kidneys can fail so like I'm no one's going to Advocate that but even if you did go off of it, you're probably have upregulated receptors for at least three or four months, which is the window where you really don't want to be at risk. So I if I was if I had been taking those meds given what you just said, I just say look I need
Just A socially isolated. I need to be more strict on my quarantine than maybe I thought it would have been before your risk level just went up a notch you you're still you're not dead. It's not a death sentence. It's just we all tweaked our Behavior based on how much we think will live, you know, when they put in airbags people didn't put their seat belts on nearly and as much just a little tweak there because I'm safe enough, right? So just you're not as safe enough as you thought you were Islam saying, okay. Yeah, it's true. Actually it comes to mind that I'm surprised.
Entrepreneur hasn't started up a website with a survey and give you a percent chance of dying, you know. Oh my God, how dirty would that be it? Look if you're not from New Jersey at least make it free or donate every single penny you make to charity because your data is all crap and we know it but yeah, we'll get just getting back onto the topic NAD is all so confusing. So NAD improves her to an activity you need in a D4 or at least 450 enzymatic.
Actions in every one of your cells without NAD you'd be dead and you need it to survive. It's very important. But is it better to have more than usual? It's questionable because there's one study that shows that NAD is very protective against inflammation and Hyper inflammation, which can lead to death in a small number of people but also it can backfire. There's a study that showed that if you block NAD synthesis, you can actually improve things.
It's a confusing. So the bottom line Dave and everyone listening is I'm still taking Resveratrol on my nmn. I believe that that is probably helping my health, but I think if you're not taking anything like that and you have any concerns about it, it's not worth the risk right now. I get a lot of questions from people and I do my very best to answer them just in the comments thread on Instagram and all about saying look at David's great that your kids are taking 16.
Mean pills a day. Yes, my 10 year olds taking 16 pills in the morning and he's happy after the first ten or up to the first and after that he's a little pissed but whatever. So the question is if I only have a small amount of money like give me a stack ranked like what are the most important in cheapest ones a D3 clearly has to be there because it's dirt cheap and it's you know, it's pretty darned effective. But and if I'm wrong there tell me what else is on your your short list of affordable things that almost everyone can afford.
All right. So the full list is in my book page 304 because I'm going to figure out some stuff but so my morning routine is the following and it's all cheap. I'm not but what am I taking that's expensive probably the NAD booster is the most expensive. Yeah, but normally I said wake up in the morning. I have one or two little spoonfuls of homemade yogurt that I think it's good for my microbiome. I mix into that tea.
In full of Resveratrol, which is it, very cheap so that Resveratrol was good. I will maybe take some corset mm or crocheting some people call it for a couple of reasons one is it seems to also inhibit viral replication seems pretty promising. What kind of dose of course it isn't.
What I take 500 milligram capsules, you know, sometimes I take two of them. It depends on how I'm actually feeling I know my body well enough that I can change things. So it core sentence good and it also increases the hafla over his virtual. Yeah, the the Resveratrol Half-Life is greater. When you take course earn, I've seen some studies around question and viral viral stuff.
And my protocol right now is I'm doing 600 milligrams. I'm doing it either two or three times a day and I'm doing the same for my wife and kids. My kids are a hundred pounds. So I'm treating them like adults from that perspective relatively high dose only for this time for this, you know, next three months or something until it's more summer. We have more natural immunity and to work past whatever the potential risks are. I think its effects with vitamin C are also pretty strong and speaking of vitamin C. What's your take on vitamin C. Yeah. So vitamin C is the next on the list.
I take a liposomal or lipid soluble vitamin C. I think that it's not going to hurt. I think I take just five hundred milligrams, which is a moderate dose. But there's a there's a lot of evidence that it can help your immunity. So I've started taking it more recently. I've what are you a huge fan for many years because my original mentors were all orthomolecular Physicians. You know what we used to call functional medicine.
For it had that name of the Linus Pauling lineage 90 grams of day a vitamin C will keep the doctor away kind of thing and you Mega dose vitamin C drips and all that the evidence is pretty strong. But for the mega dosing protocols that have been used for helping all viruses. We take it to bowel tolerance where you just keep taking it until you get the runs and then you back off a little bit and you do that for three or four days while you're recovering there's this has been used for a long time. There's some pretty good evidence there you can't do with lipids normalcy. So
I love the daily lipoma see but you'd get so much fat to get 20 grams of vitamin C in your body that you've literally be pooping lipice. Ohms and you wouldn't be absorbing it and that's gross. It's much worse than the vitamin C poops. So you gotta have some straight ascorbic acid which by the way, if you buy a pound of ascorbic acid powder almost everyone can afford that it's a little bit more expensive than flower, but it's not that expensive. Okay good. Zinc is very cheap right now. It's a good idea to take Zen cup taking 40 milligrams a day milligrams of its
It does what flavor of zinc do you like?
Mine just is tastes like chalk. I mean like zinc gluconate zinc oxide have to go check on the on the container. It just says ink on the I didn't look at what type okay. I'm a fan of sink orotate. That's that's what I put in the zinc copper formula that I did for bulletproof just because the or rotates a fit into the mitochondria stack in a different way than most things but there's think monomyth. I need different flavors. I would say this point unless
You're also doing some gut problems. There's almost any form of Zinc is good. But zinc carnosine works really well for people with GI problems in a special way, but right now and he's think is better than no zinc. Okay. What about copper? Is that on your list? No, okay. So repay, you know the balance of zinc and copper can get out but without copper testing. I tell most people take low doses of copper if any because half of us are copper toxic the other half have too much zinc and we're in balanced and it's messy
See so in my firm and I put some copper but not as much as I did zinc so I could capture the biggest share of people who needed it. Okay? Yeah, so the something that I've added to my diet recently there was a publication that came out since we last spoke that said that oleic acid is both an edible form of a sir to an activator and is produced when we're fucked when were fasting when we're hungry how fat degradation produces oleic acid and it works exactly.
Polly down to the molecular level the same way where is virtual works? It binds to the cert one enzyme and activates it this accelerator pedal. So I've using more olive oil fresh olive oil in my in my diet in it is dressing on salads, but I also researched this fairly extensively. I have a little capsule gel cap that has a whole bunch of different oils in it, but very high level of oleic acid and yeah, it seems to
Be very healthy when I looked at the effects of this molecule. Very cool. I hacks haven't seen that one study, but there are other studies in one of my herbal manuals for viral and bacterial stuff and they do talk about hydroxy tires all which is another major component of olive oil. And so I do in my regular salad, it's half brain octane half olive oil vinegar and whatever other stuff I want to blend together avocados and whatever else to make it. I took prebiotics in there, too.
But I I also take a hydroxy tires all capsule which has about a hundred bottles worth of olive oil in it sort of like the Resveratrol of wine. But hydroxy tires. All is the Resveratrol of olive oil if that makes sense any thoughts on hydroxy tires all or is that outside year sphere of influence? Yeah, that is outside of I'm gonna now look at our it's cool stuff. I put a little bit of it in I think it's in my Omega krill oil if I remember I put a bunch of other stuff in there that isn't normal, but I'd have to go back.
Look at my ingredients to see I know I've lobbied for it. But whether I got it past my regulatory people. I don't know. Okay. Well we could go all day. I'm taking alpha lipoic acid. I mean how much me too it's a pretty large capsule. I'd have to check but it's probably 500 at least five. Yeah. It's about 500 I guess. Yeah got it. So I'm doing a la ugh one gram morning and night for my body weight. I'm about in 205 right now. So my kids are getting
Getting it once a day. It's in the morning. They didn't used to get it but I've added it in recently. Yeah. Well, it's actually it seems to be helpful for viral infections. Yeah, I didn't realize that. Oh and you know how think a lot of people would have read in the New York Times or elsewhere that a loss of smell is a potential symptom of of covid-19. And I looked up what what's the cure or what's a potential cure for that and it was alpha lipoic acid, which was great news because I was already taking it nice.
And I'll tell you very briefly why I started taking it. There's a there was a scientist who's now unfortunately passed away, but he was his name is denim Harmon and he was known for the free radical Theory of Aging famous guy and I yeah, I managed to meet at least his family. He was in his 90s and at home when I visited but they said his family. Let me in on a little secret which was that I denim has been taking had been taking this alpha lipoic acid for years most of his life.
Life mostly thinking that it was an antioxidant and he worked until his early 90s. And so I figured well if it didn't hurt him what's his thinking and it goes on guinea pig but as a really smart guinea pig, I like that what about within alpha lipoic acid? There's the normal cheap stuff. There's our this also our alpha lipoic acid, which is racemic and the first guy to launch that came to me and
I want to say mm. I've before anyone knew what I was doing and we talked about launching something and then there's also potassium are alpha lipoic acid. Do you go for the fancy stuff for the cheap stuff? My name's Al so just the bulk cheap stocked up. Okay, cool. Is it am I wasting my money? I don't think you're wasting your money, but there's there's more efficacy from the R vs s form, you know, it's hard to do that. How about in acetylcysteine? Do you do that one?
No, not regularly. Okay, I've got so many things working on. My mitochondria have to be careful speaking of which I take co Q 10 how much good looks pretty like a about a mill or a gram of it. It's pretty big capsule that I take. It can't be that I mean, that's Mega. I could just quickly go next door and my back but it's a capsule. I mean, it looks like 400 but it's for big gel caps that usually about the most you'll find in any Capsule. That's Mass.
All is about 300 milligrams. If you're spending hundred dollars on a bottle. Okay? Well, it's a large thing that I can barely get down my throat. Okay, whatever that it's probably between one and three hundred you're taking one of those or
it just wanted I've done that for a decade or more smart. If co Q 10 is just like table Stakes for mitochondria from from my perspective. Yeah, and I'm often criticized for taking a Statin you're a bad person took a pharmaceutical and there's some evidence that they can be hard, you know side effects, but I've got to take it my medical history says that I'm going to have a short life if I don't
Take one of these things. I'm going to megadose of statins and I think most people know that you've got to balance that with like you to insult your why is to do that and it look if you look at the data, there's a risk reward for every single substance that you might possibly use including statins. And if for you individually the ROI is there you take it and whatever people say, I will never take any pharmaceutical drug like you're lame and even I will you know, all vaccines are evil.
There are cases where vaccines can cause some harm but there are also some cases where you know, the risk reward is probably worth it for you.
Question on vaccines syntax. Are we done with our supplements are there more supplements and I want to go into covid vaccine. So that's going to be fun with you. Let's do that going to vaccines. All right. Sure. So people are saying we're going to have a vaccine soon. I did a video on vaccines where I talked about the amount of time it took to come out with vaccines going back to swine flu and H1N1 and all the different ones and how we have an almost perfect exponential Improvement in the amount of time. It takes to bring a
during a vaccine to the the Final Phase of regulatory approval. So in other words our scientists are getting better at making these vaccines. So are you hopeful that we're going to have one is it going to work? Is it going to be like a flu vaccine? You're supposed to take it every every year if you decide it's worth the trouble like what where are we on this? All right. So here's my take having talked to a number of experts on this. The the Chinese are ahead of us a China is ahead of the u.s.
I start that a few months Head Start and they can also go quicker. They have you know, less bureaucracy interesting whenever they wanted is great over there. Right? So what you agreed with that David you're supposed to say no, it's true. But it may help the whole planet. It means agreement with China and the Chinese population helping us with knowledge. It's pretty cool. Actually. It's
Really good anyone who says that this is a Wuhan virus and puts down the Chinese. It makes me really bad. It's unacceptable. Yeah, so getting back to the vaccines. I think that it's true. It's going to probably be 18 months before something is approved for wide use in the u.s. Now if the Chinese tests go fast and they find that it's safe. Then I'm hopeful that we'll be able to use their technology or they'll start selling us vaccines will be probably desperate enough that
We'll take that on that is at least 12 months, right? So that's the minimum most likely if we depend on American companies. It's going to be 18 months. So why is that now? Yeah, there are some great Technologies. Well, we'll get erect these summer donor has new technology. They started that their clinical trial exactly a month ago, but you need to go through various phases not like you just inject 10 people and if they don't get sick,
Nick you're done with it. There's multiple phases and even though I'm sure the FDA is trying to do their best. They are aware that vaccines can backfire and I'm not talking about the usual stuff that people worry about with vaccines the aluminum and the all the other stuff and I'll bunk with boy.
Oh, yeah, even the aluminum side.
Oh, yeah, I'm very interested in your take on that. I'm not going to take you off track here because it'll just like create huge tribalism and anger there. Well, I'm going to I'm going to have that hate mail, but I'm a scientist. I have to tell you that I will absolutely listen to what you're saying here. I will take more convincing that aluminum isn't a problem. But I also it drives me nuts with you like all vaccines are bad. I'm like, you know what it's like saying two liquids or bad. Could you tell me which vaccine for which human being at what risk level and then we'll talk otherwise STFU that's what we'll do.
In 2000 people potentially die now is not the time that complain about vaccines there. Are there are main savior. Okay, what about sold by the way? Okay Vaughn on the aluminum self the the group that published that aluminum was correlated with Alzheimer's disease with debunked. The aluminum was actually coming from their mission. It's not actually correlated with Alzheimer's disease. There was a big piece done with almost a hundred different references about the effects of aluminum systemically, uh neurological
Nation and all these other things that was the one that was it was done maybe 10 years after the aluminum Alzheimer's thing that got me thinking about it. But you know, I'm I remain open-minded and questioning and I wouldn't take the covid-19 vaccine along with every other vaccine that's been made all the same time because I think it might cause harm. Well I can say something on that. So it is true that if you have multiple vaccines with the same virus or the same protein,
Over a couple of years and even three years it's been shown he can have us a slightly less response, but we're not going to be taking the same vaccine and we're not going to be taking them all at the same time like you said and so it's you know, I think people are generally looking for any chink in the armor and there are small things like that. But that doesn't mean that we shouldn't try to save the entire planet right now with vaccines. Okay. I'm actually an agreement with you. They're like look.
You know if we could do with lasers from space, I would look at that to it doesn't matter like show me a tech that works and I'm going to go for it. Yeah, so the 18-month timeline the reason that it's probably going to take that long is that the FDA has to be very careful. There was a monkey study done with the tsar's one and there was a vaccine that was directed also at the spike protein that is how the current vaccines are being developed for the most part and those monkeys actually did worse that it triggered the immune system to overreact it's believed and so it
It's not just a matter of oh, let's make this and give it to people and hope for the best that the government wouldn't allow that because Millions hundreds of millions of people are going to be vaccinated if you think about it, all of humanity is probably going to be vaccinated if you haven't had it before it's okay. So all of us are going to be vaccinated if you haven't had it before that's that's brings us to natural immunity. And this is something that's been pretty controversial. I've said on a couple other podcast, but I want to get your take as a researcher on this.
I live on 32 Acres. I can self isolate like no one's business. I've got enough Bacon walking around the backyard to last me for years. Okay, so so truly self-sufficient if I could get a coronavirus now being a healthy human being with lots of resources on site very unlikely to clog up the hospital if I could get it and have natural immunity, which would let me go out into my community and help older people shop and you know carry groceries at the hospital, whatever right I could do more.
Than I'm doing now. I feel like it would almost be the right decision to be one of the people with natural immunity because it's a superpower right now in there have to be other people thinking about that. Is that good? Thinking or bad thinking that's really dangerous especially for you and me. I think we're roughly the same ages now, we're both very healthy and we do our best but there's still a reasonable nonzero chance that we will either clogged.
Up a hospital bed when others needed or we will die and there's a third thing you have to really be careful about and that is that if the body over reacts to your virus, you know, let's give it a five percent chance that's going to happen. You might have long lasting damage to your lungs and to your heart. There's fibrosis that builds up in the these cases and a lot of doctors including Peter a teacher who's been great about educating people think oh well,
We were worried that you know, five ten years from now people will have these issues with their organs. So it's not like oh you just get it you get over and done with and then you just become Superman. I definitely understand there's a small percentages and also those percentages are for people who smoke and are do average things and there's also okay if you're doing your mega dosing co Q 10 are you in the cardiac problems from this the odds go down if you have intravenous vitamin C in the refrigerator behind you the odds of having problems.
Is go down if you have inhalable lung steroids for inflammation on on hand, which are downstairs the odds of this go down. You have ozone therapy sitting right next to your desk the odds of this go down. Like I kind of like I can handle my shit. I know you're bulletproof. It just like a can I bring the has low enough that all right. I took the head and now I can go do good things. I mean even under those circumstances you think our risk is so high just because of age. I mean, you're a healthy guy.
Yeah, well is the risk worth it? Yeah it we don't get a second chance of this it then again. Do you believe the estimates that 50 to 70 percent of us are going to get this. Anyway, I do.
I do so I got it. Now you handled it well, and then you could go help other people not die from it. Wouldn't that be the moral choice? Oh, I see where you're going you're willing to take this risk.
Yeah, I mean there's something about that. But what I don't want to do is encourage young people to just go out and party. No, that's not what I'm saying. Like they will probably some of them will die because the ones who really want to go out and party are probably going to think they're healthy young people in there. Not an alcohol. Good God don't drink during this time. The that's probably a dumb decision. At least that's my opinion. Do you agree? No, I actually think drink alcohol is good for for it's not good for you. But I find that having a glass of red wine with
My family is fine. Even from a general immunity perspective. You have any research back in this effort? You just like that. It gives enhances your Gaba receptor. So you can chill at night. It's a glass of red wine. It's not hard alcohol and I don't drink a lot but it does allow me to you know, relax with my family and it's a social thing as well. And I don't think one glass of wine a day is going to be a problem. So it's kind of like half a valium or something it just kind of helps.
It does I'm a pretty active stressed-out ADHD kind of guy in your brain goes really fast. And that's a compliment. I mean, you're a brilliant guy clu is symbol things and how rapidly you do it and is sometimes turn your brain off its work. I'm I'm with you there. Okay cannabis good bad.
Well, I know that the dispensaries are all open in Massachusetts and California essential medicines. You know why they're essential though?
No, they're essential because when they said they were going to get shut down everyone on Earth went and got in line and started spreading the virus. So they said we're going to keep them open. So people will respect social distancing so they can go buy their pot. I'm not even kidding. Oh, no, I didn't know that.
Yeah, I don't see major health benefits. I'm not I'm not keen on major health issues. I'm not keen on putting anything particulate in our lungs smoking. It's a bad idea vaping. It's a bad idea right now. But okay, you can still eat it or patches or whatever. Yeah. Yeah. I'm I don't do it myself, but I have no knowledge of any downside was CBD oil activating endocannabinoids receptors to modulate inflammation is there's some you
On this there. Should I prophylactically hit myself with some THC free CBD just in case
well, so yeah, potentially. Yeah, I put it on the maybe list if you have a bunch at home, I do it it's not on my list of must-haves low dose Naltrexone.
I don't know. I don't know. Okay, again, no evidence for viruses, but for modulating inflammation, if you're one of the people who it already works for fraud immunity managing out immunity seems like a good idea. I mean it's in my anti-aging perspectives in my book. It's one of things. I don't know either but it's probably not a bad thing, but I wouldn't go seek it out right now. What else is on your list?
Well, so cvd is CBD oil is good for relaxing and going to sleep. So if you have sleep problems, let's talk about sleep. I think that's a lot of pain a lot of people's minds so I don't do so sleep remedies. Yes, I have a sleep mode and I make the glasses the true dark glasses of patented for sleep, but you can pitch whatever you want as long as it works. I this is not about selling. This is about informing the shows always been about it for me. I talk about other vitamin companies whenever they make good stuff that I don't make so tell me what you got.
So I use your glasses that I prescribe those. Thank you. Yeah, but so I've had a great I wouldn't not I would wear them every night. I would recommend that. So anyway getting back to the product. I just started trying something and I'd be interested if you have something similar it's called dr. Parsley's night remedy and it's been working really well. Oh I know and it's kind of Kirk just lie. He's a friend the
it does work well, but last time I checked the formula he had something called phenol Gaba in it. And I used to use phenyl Gaba and something called Gaba wave is very early bulletproof product. But funeral Gaba is a great Market non-fda-approved. They consider it to be a drug. And when you add a phenyl group to a Gaba the Gaba becomes much more bioavailable, but it sticks around for a long time. And then when you have funeral Gap with a six around for a long time, it has addictive.
Properties and has a 36-hour half life in the body. So anything with phenol Gaba is going to make you sleep really really well almost as well as GHB. It's one step removed and GHB is great for sleep. If you could get it. It's just, you know, an illegal street drug now even though it used to be asleep supplement. So what I would say if you're going to take anything that contains phenol Gaba is you need to space it out every other day and do not ramp up your dosage because you might not like what happens good advice and I
But it tastes very sweet. I have to make sure that there's no fraud case of think he would do that. It's been a while since we hung out but no, I like Kirk, you know, maybe still sleep doctor types tend to be into things. So he's cool. All right, anything else you do for sleep or for supplements? And then I want to see and then I want to ask you two more questions and then we're going to go into our Instagram sharing session.
Well Jo, we've covered a lot of supplements or we filled a whole bucket with me we did and we could let's talk about testing really quick a big thing. That's happening is people are they're using PCR testing which is where you take the DNA and you amplify it many many many times and then you see what's there and there's also antibody testing and there's also direct virus testing how
You have concerns about different kinds of testing about availability about reliability. Its kind of walk me through the testing universe that you're aware of for covid and where we are and where you think we're going to be. Well the US really screwed up the CDC that their tests were not reliable and a lot of scientists are angry about that because it was a fairly simple mistake as far as we can tell bad design of the primers and it wasn't detected till a few weeks.
After the test had come out, so that's the main thing. So what I've been doing in my small capacity is reaching out across the planet to see who needs kids and I can tell you there's a lot of desperate people out in the world companies and hospitals and then connecting them to manufacturers including a very large the largest genetics company in China who's making these things by the hundreds of thousands of eventually Millions. So there are three types of tests the
That most people are using is what you what you said the PCR the preliminaries Chain Reaction test, which is a DNA amplification test you turn the RNA in the virus into DNA and then you Amplified you get a signal and it gives you an idea of how much virus there is and also whether it's present. It doesn't tell you what strain of virus it is. You don't know which mutations are in there, but it's the most reliable one. That is a real pocket that one how much does it cost?
well
You cannot get it you look in the mirror. And if you have us if you have a fever you have covid there's your test. Yeah, there are home tests. I have one here in my home. But I well first of all tell you the test. It's a it detects antibodies that you've made to the virus and it can detect it within about 15 minutes. It's like a pregnancy test to put a drop of blood or serum on there and but but what I heard was that these home tests
To verify this because I find it hard to believe is that the FDA has banned the use of testing at home, which would be really bad news. And I think how are they even allowed to that my body my biology my rights what jurisdiction do they have over my blood if you actually did ban that this is a fundamental human, right? You don't have a right to my information. And if I want to get a bogus test from some weird astrologer person. It's my right to do that. And I would appreciate your validation of the test that I Do by an hour.
By the test you validate but do not block me from doing things that I choose to do. Like that's that's nasty. But Dave you're not qualified absolutely take my license right now. Well, you can't I thought you meant on the average person though. Oh, I see you're saying I was like, I have no medical license. I'm not a doctor, right but the the fundamental human Freedom here it is that now I'm not qualified but when it comes down to hey, I would like to know what's going on my body if I want a
Test I shouldn't need a permission slip for it, but it should come with a big sticker that says the FDA either doesn't has invalidate this test or thinks it's a bunch of crap. But hey, you know, I'm allowed to buy popcorn. That isn't very good for me. So why should I be able to buy a test? That doesn't work? They're regulated by the same agency. Right? Right. If you can smoke then you know, that's far worse for you. Then the third type of test is the DNA sequencing which gives you every letter in the 30,000 letters in the Genome of the virus. That's the most accurate.
Turret it gives you beautiful data tells you exactly where the virus is coming from The Strain the mutations in it, but that takes overnight to do and it's a it's a few hundred bucks per test. But that is the best test and I think eventually when we do an autopsy of what's happened across the planet those type of test will be important. Actually what's really interesting is you can go to a website called Next strain dot-org and look at the evolution of the virus across the planet and in almost
Real time and you can see the mutations that are popping up every few days. And now the question is are those mutations bad or Google for the virus and inversely for us. We don't know yet. I'm mostly they are benign that I make a difference, but there is a small risk that it'll make the virus immune to our vaccine so to speak or it could even become old lethal. So I'm following that closely.
Okay. I'm I have not ordered any test kits I do have because of the relationships that President similar ones what you have I do have access to be able to order a variety of either antibody tests or the PCR tests. I'd rather those good health providers. I don't I don't think that I need them for my family if we get a sniffle we'll just deal with it. We're isolated like it. It's okay.
David's good news if you get a sniffle because it's probably not covid-19. Exactly. Right and even if we had some of the minor things it was not getting worse. No, but I think hoarding caskets are having them just in case you can be fatal. What are you going to do? Like if you're if you're sitting at home and you test positive either you're not going to need to go the hospital or you're going to need to go to hospital and if you're at home and you don't test positive either you're going to have to go to the hospital or not go to the hospital if it's just the flu or just anything else. So in terms of actionable stuff for you, you already should be selfish.
Waiting so I mean do we need test kits unless we can widely distribute them in which case of course we need them so we can map the thing out. But until then, I mean should we only reserve them for high-risk people? I agree. I think that it's the same for chloroquine or plaque. Well as it's known right now the doctors that are that I know that are on these on the front lines as we say, it's it's desperate times and we need to keep them healthy. Otherwise, we're all in trouble. I have one more question for you.
But what I think we should do is let's get onto Instagram. I'm gonna ask you this question on Instagram on the day of dot asprey channel. So I'm going to go on Instagram first. We're going to stay on video Stay on audio here. So people can hear me ask the question and they can hear your answer to it. And so if you're listening to this on iTunes or something if you follow me David a spree at the end whenever I'm recording a live show, I'm going to do an Instagram with guests going forward because it's pretty cool. Just put them on my Instagram stories. So
give me one second to start a story here.
All right. Here we go.
Hey guys.
Thank you for joining David. Sinclair is coming on board right now. I'm going to get him to join as soon as he requests to join the live.
I've got him on the podcast. We just finished an epic podcast. I mean, it was really good. I'm going to put this out as soon as humanly possible and this is a guy who's actively working at Harvard as a researcher on how we're going to live way longer than we're supposed to and the author of Life Span and you're going to get to ask him questions after I get my first question for him, which is going to be the last question that you hear in the interview when you listen to the whole interview on bulletproof radio. There we go. I see your request David.
And David Sinclair PhD added. All right, good deal. So my question for you, and if you're just joining in guys, this is David Sinclair Harvard researcher author of Life Span and one of the really brilliant superhuman researchers out there guy behind NAD + NM n and Nick autonomy driver side and all that kind of stuff. So first off welcome to the Instagram live and then ask you this big question. They're supposed to say hey. Thanks Dave. Hey, thanks. Dave told me what to say to you.
That works. Okay. So we really we're rocking this the table are all going to die. All right, none of that crap. All right, here's my big question for you to cap off our interview on bulletproof radio your general outlook on the virus. I like what's this going to do to humanity from an immune perspective from a societal perspective and your spent three weeks going really deep on the virus looking at what it does looking at how it's affecting populations. Where are you now? Well, it's like as I kept telling my wife Sondra the kids are not going.
Just go anytime soon most experts. I talked to who actually understand epidemiology think that.
We're not going to go back to normal as a society probably for another year. We will go back to work just like China so don't don't panic about that. The economy is going to get back on its feet hopefully soon, but life will not be the same for probably a year maybe even to the virus is not going to go away by itself either we half of us have to catch it or we need a vaccine, which maybe we'll come from China in the next 12 to 18 months.
Or one of the US companies will succeed in about 18 months or longer and we just hope all that one of them is going to succeed but I think that for Humanity there's it's not all doom and gloom what makes me proud of humanity is that if you think about all of the history of life on earth going back unless you believe in creation it goes back at least three and a half maybe four billion years. That's a long time. Right? And this is the first time ever that a species.
That's all over the world has United to fight one fo so I gotta tell you if you're listening to the show and you think the shows with your time. There's a couple things you do and number one go to iTunes and rank the show. Give it some Stars if you like it number two go out there and support David is researchers work in the world read life. Span number three do the same thing for superhuman because the stuff in those books is going to help you be resilient whether or not there's a pandemic whether or not you're locked away at home. So now's your time to read to learn and to take action on
Making yourself superhuman so that you'll have a longer life span. See what I did there and you'll actually be able to weather whatever life brings you even if it's some stupid virus on that note stable approve. See you next episode.
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