Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan

STEM-Talk Go to Podcast Page

Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan

Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan

STEM-Talk Go to Podcast Page

STEM-Talk

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44 Clips

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Jan 28, 2020

Top Moments

One of the best predictors of mortality is cardiorespiratory fitness.

0:05

To Extend Your Healthspan, Exercise to Improve Cardiorespiratory Fitness

Aging is the greatest risk factor for nearly every chronic disease and morbidity that people face.

0:04

Adam is Studying the Effectiveness of Rapamycin & Metformin in Delaying Osteoarthritis

Metformin mitigates the exercise-induced improvements in insulin sensitivity and cardiorespiratory fitness through its inhibition of skeletal muscle mitochondrial adaptations.

0:13

Adam Expands on His Finding: Metformin Blunts the Beneficial Effects of Exercise

No matter what, exercise is important ... Exercise is a valuable and effective strategy to improve our health.

0:10

Metformin Blunts Exercise's Beneficial Effect on Insulin Sensitivity

Intros & Ads

STEM-Talk Intro

0:05

Dawn & Ken Intro

0:20

Dawn Introduces Dr. Adam Konopka

0:42

Ken Reads This Episode's Winning STEM-Talk Review

2:27

Ken Introduces Dr. Adam Konopka

0:05

STEM-Talk Intro

0:04

Dawn Introduces Her Co-Host, Ken Ford, and Dr. Adam Konopka

0:12

Clips

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Why Adam Decided to Establish His Lab at the University of Illinois

0:28

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How Adam Became Interested in Competitive Swimming

0:45

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Adam's Interest in Competitive Swimming Led Him to Major in Exercise Science

0:36

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Adam Minored in Entrepreneurship Because He Wanted to Start His Own Business

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business entrepreneurship

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Adam's First Research Experience Was Focused on the Health Benefits of Exercise

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Adam Once Studied Muscle Mass Loss in Astronauts

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Elevated Mitochondrial Reactive Oxygen Species Production May Reduce Insulin Sensitivity

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Exercise Reduces Mitochondrial Defects Associated with Obesity and Insulin Resistance

1:36

exercise obesity

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Adam's Research Aims to Translate Cell Culture Findings to Improve Human Health

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Metformin Doesn't Inhibit Glucagon-Stimulated Glucose Production

1:08

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While at CSU, Adam Studied the Joint Effect of Metformin and Exercise on Metabolic Health

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Adam is Studying the Effectiveness of Rapamycin & Metformin in Delaying Osteoarthritis

2:52

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Adam is Studying How Rapamycin Inhibits mTOR in Muscle

0:36

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Adam Has Been Studying the Interaction of Exercise & Metformin Since His Post-Doc

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Adam Expands on His Finding: Metformin Blunts the Beneficial Effects of Exercise

1:54

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Metformin Blunts Exercise's Beneficial Effect on Insulin Sensitivity

1:06

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The More Metabolically Unhealthy, the Greater Potential Benefits from Exercise & Metformin

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Adam Plans to Study Metformin's Effects on a Range of Metabolically Healthy Individuals

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STEM-Talk Interlude

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Is it Possible to Pulse Metformin Intake to Limit its Adverse Effects on Exercise?

1:42

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The Higher Your Type 2 Diabetes Risk, the Less Metformin Inhibits Exercise's Beneficial Effects

1:36

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Metformin Inhibits Exercise-Induced Improvements in Mitochondrial Respiration

2:08

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The TAME Trial Isn't Designed to Determine Whether Metformin Extends Healthspan

2:11

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Ken Wishes the TAME Trial Utilzied Rapamycin Instead of Metformin

0:43

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Adam Believes a Metformin Trial in Healthy Individuals is Warranted

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Metformin May Only Extend Healthspan in Individuals at Risk for Type 2 Diabetes

1:38

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How Would Adam Design a Healthspan-Extending Intervention Trial?

3:10

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If Adam Were to Study Metformin's Effect on Healthspan, How Would He Adjust for Diet & Lifestyle Variables?

1:16

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Will Pharmacological Methods Prove More Effective at Extending Healthspan & Lifespan Than Exercise?

1:55

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PPAR-D Agonists Are a Class of Drugs That Mimic Exercise's Pharmacological Effects

1:11

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To Extend Your Healthspan, Exercise to Improve Cardiorespiratory Fitness

1:06

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Adam's Exercise Routine Includes Lots of Endurance Running & Biking

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How Endurance Training Changed Adam's Fast-Twitch/Slow-Twitch Muscle Profile

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Even with a Young Child, Adam & His Wife Exercise in Their Spare Time

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Adam, Ken, & Dawn Outro

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Dawn & Ken Outro

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Rate & Review STEM-Talk

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Topic: 48i

STEM-Talk Intro

STEM-Talk Intro

Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan

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STEM-Talk Intro

Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan

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Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan

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