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Vigorous-intensity exercise, like high-intensity interval training... it's one of the most powerful stimulators of mitochondrial biogenesis ... When you're producing greater amounts of lactate, that actually activates one of the major pathways that regulates mitochondrial biogenesis. It's called PGC-1alpha. And again, lactate's acting as a signal to produce more of that PGC-
1alpha.
Rhonda Patrick
Lactate Generated From Vigorous Exercise Stimulates Mitochondrial Biogenesis Via PGC-1alpha
The Longevity & Brain Benefits of Vigorous Exercise | Dr. Rhonda Patrick
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