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One of the things that caffeine does is it is a fairly potent PDE inhibitor. By being a potent PDE inhibitor, it indirectly stimulates IGF-1 ... By ingesting caffeine or by applying topical caffeine ointment or cream to the scalp, you can suppress PDE sufficiently enough to increase IGF-1 and increase some hair growth, or at least maintain hair growth in that
region.
Andrew Huberman
Applying Topical Caffeine to the Scalp Increases Hair Growth By Stimulating IGF-1
The Science of Healthy Hair, Hair Loss and How to Regrow Hair
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