If you ever look back and say 'Hey, where did we get this idea that we should eat six or eight times a day?' From nowhere. Somebody made it up, it stuck, and that was about it.

I think the biggest benefit of time-restricted feeding is the psychological one ... People think intravenous access to food is essential for life. If they go more than two hours without a meal, the sky is gonna fall. So, in many ways, time-restricted feeding is just a way to prove to them that is total nonsense.

When you look at what happens to the body during fasting, in fact, the body doesn't shut down; it actually revs itself up. It actually increases noradrenaline [and] increases growth hormone. So, because you're increasing your sort of fight-or-flight response, which is your sympathetic tone, you're actually more focused. You're actually going to be able to concentrate better.

The standard advice to eat less and move more doesn’t work. We all know it, and the studies all show that it doesn't work. So, why shouldn't we use this tool that we have [fasting], which is honestly the most powerful weight loss tool? Because you cannot go lower than zero calories ... This is the most powerful tool, and we’ve decided to not use it? Are you kidding me? That's gotta be the craziest thing I’ve ever heard.

If you think about the number of diseases that you can make better—heart attack; stroke; cancer; diabetes, which is the leading cause of blindness, of kidney disease, [and] of amputations—the secret to managing all of these things is not more medicine and surgery; it's less. It's actually within our grasp because fasting is free to every single person on Earth.

A lot of people will say that type 2 diabetes is sort of chronic and irreversible and progressive; it's actually a total lie. Type 2 diabetes is a completely reversible disease. It's simply too much sugar. You need to empty that sugar bowl—that's the whole idea, and that's how you reverse it.

When you actually look at the science of what happens during fasting, it's actually one of the best things you can do for yourself from both the mental standpoint and a physiologic standpoint, assuming, of course, you're not malnourished.

We know that cortisol has a huge impact on body fatness ... If you get good sleep, you're more likely to be at a good weight. If you are sleep-deprived, for example, it's a stressful situation where cortisol is going to go up, then you're more likely to gain weight.

You have three nutrients sensors: You have insulin, you have mTOR, and you have AMPK ... Insulin responds to dietary carbohydrates and dietary proteins. mTOR responds mostly to dietary proteins. AMPK actually measures the AMP to ATP ratio, so it actually doesn't care about what you eat; it just cares about the cellular energy availability.

Dr. Peter Attia recommend patients supplement with phosphatidylserine and GABA to aid sleep during a prolonged fast.

Meat is probably one of the most nutritious foods there is.

In the fed state, insulin goes up, you're storing calories or body fat. In the fasted state, you're not eating, your insulin is dropping, and you're using calories. So you're one or the other—you can't do both at the same time.

If you look at studies, the average duration of how long people eat for is about 14 hours and 45 minutes. That's the average. So, if you start eating at 8 AM, you don't stop till 10:45 PM. That's on average.

35% of cancer can be attributed to smoking, and 30% is diet ... Pesticides might be 1%, and radiation might be 2% — it's negligible compared to the diet.

Intermittent fasting just happens to be one of the better-studied ways to maintain your basal metabolic rate.

Fasting is what I call medical bariatrics. You get all the benefits of bariatric surgery without doing any surgery.

At this point, the World Health Organization considers 13 different types of cancers as obesity-related cancers.

High insulin, for example, blocks fat-burning. You can't burn your fat stores because your body's like 'The instruction that I'm getting is to store energy, not use energy. I want to keep my stored energy for when there's a time that there's no food.'

We see this all the time... As you prescribe insulin, people gain weight. You give sulfonylureas, which increase insulin, then people gain weight. You give them SGLT2s, which make insulin drop, then you lose weight.

The biggest one, of course, is tobacco smoke. So, that's sort of, by far and away, the biggest contributor to cancer.

People say 'You should eat multiple times in the day, six times a day. It's good for you.' But nobody in the history of humanity has done that before.

I think it's more likely that the hyperinsulinemia is driving the obesity rather than the other way around.