Generally speaking [with supplements], the greater the effect, the greater the side effect. If you don’t know what the side effects are, and the supplement has a very high amplitude effect, then you’re just the sucker at the poker table who doesn’t realize he’s the sucker. There are very rarely free lunches when it comes to biochemical enhancement.

If you hire the right folks and you can trust them, then you can hand them the keys to the castle and let them go run with it

Failure isn't a bad thing. It's just admitting that you've learned something.

You can get the same benefits of longer duration exercise, and maybe even more brain benefits on the neurogenesis side of things, by doing these really intense short sprints

Time management is important, but time management doesn’t matter unless you have attention management.

Supplements can become a crutch for people who aren’t paying sufficient attention to their diet, sleep, and other parameters—they become a Band-Aid to cover other bad decisions.

I feel that one of the greatest issues we face today, especially in the United States, is this idea of experience stretching ... Everything that you own is a small burden on you.

Looking back on the last decade, the one thing that I didn’t do soon enough was admit to myself and others that I didn’t know certain things. The quicker you are to come forward with the fact that there’s a hole in your knowledge, the quicker that hole will be filled.

For me, luxury in a way, more than anything else, is the feeling of being unrushed.

If you're thinking about having some caffeinated tea, but you don't want to have a ton of caffeine... the best thing to do is steep the tea for about 30 seconds and then pour off that first steeping because 80% of the caffeine is released during the first 30 seconds of the steep

Strong convictions, but loosely held

When I get quite a bit older... I think I might take up pipe smoking ... The smell of pipe tobacco is so incredible. I think I just want to be, like, a cantankerous old guy in a rocking chair on a porch, smoking my pipe.

My priorities from a training perspective... would be conventional weight training once or twice a week, probably no more than that. It's really to... make it a little easier to maintain healthy glucose levels. If you are increasing your muscular mass, particularly if you're doing these workouts prior to a meal, your glucose disposal is just going to be improved. GLUT-4 transporters and so on will be more effective at doing their job.

...There are cells in your body that could potentially turn cancerous and if you starve them, because they are already weakened and a little messed up, they will die first.

All the data around sauna usage points to 20 minutes being the sweet spot, at a temperature of 174 degrees Fahrenheit

I think, like cryptocurrency, it's going to be a multi-metaverse world where it'll be about just the ability to move and traverse through different metaverses for different use cases and moving your items between different metaverses.

If you want to get out of your monkey mind, at least for me, one of the fastest ways is through the body. And it doesn't take a lot. It really doesn't take a lot. Get outside, walk for a few minutes, jump rope for three to five minutes, and then go back inside.

My biggest regrets in all of investing are actually the times that I sold prematurely ... It's not having missed opportunities to invest; it's having not held the things I invested in for a long period of time.

Psychedelics, in a proper setting with supervision, can provide one the opportunity to do a radical self-assessment that shows you where your blind spots are and where your stories & software are out of date.

I think it's easy for people who lift weight, in some fashion, to be heavily biased against bodyweight or calisthenic-type exercises, and it's very easy for people who do bodyweight calisthenic-type exercises... to glance askance at people who are lifting weights. And I think they are very, very complementary. But man, I have seen some gigantic bodybuilders and powerlifters do a yoga class and just end up on the floor because it is a different exercise.

People get so caught up in these bull and bear markets and watching these coins... I try not to get caught up in the weeds there and just zoom out even further. Because I think once you do that, the lines start to smooth out a bit, and you understand that we're in the very early first innings of this entire rewriting of the financial stack.

'Adversity doesn't build character; adversity reveals character.' You want to know that your partner can navigate rough emotional waters when things are difficult, and not immediately pull out a gun and shoot you in the face.

A lot of people who pride themselves on being achievers spend the vast majority of their time whipping themselves.